It is currently the only skin patch that is approved to treat this condition. Who Makes It? Monoamines are special chemicals that carry messages from one brain cell to another. These messages can include information about many things, including your emotions. Some examples of the monoamines that help transmit these messages include: Dopamine Norepinephrine Epinephrine Serotonin Melatonin. Histamine. When a message (electrical impulse) reaches the end of one brain cell, monoamines are released into the gap between the cells.
Here, they quickly travel across the gap until they reach a receptor on the next cell, settling in like a key in a lock. This triggers the electrical impulse to continue through the next cell and on to its final destination. Once the message has been transmitted, the monoamines in the gap are either reabsorbed by the first cell or broken down by an enzyme called monoamine oxidase (MAO). There are two types of monoamine oxidase enzymes: MAO- A and MAO- B.
If a person has low levels of monoamines in the brain, it can reduce the amount of communication between the brain cells and cause the person to feel depressed. MAOI medications improve the communication between brain cells by blocking the action of monoamine oxidase. This increases the amount of monoamines in the brain and thus improves a person's depression.
While most monoamine oxidase inhibitors work equally on both MAO- A and MAO- B enzymes, Emsam works more on MAO- B than on MAO- A.
I have been on EMSAM 6mg/24hr transdermal patch for 12. Something interesting about EMSAM. Before starting EMSAM I was concerned about increased anxiety. The EMSAM patch is a unique monoamine oxidase inhibitor (MAOI) being the only antidepressant utilizing a transdermal delivery system. This was welcomed by. But it can be used to treat anxiety as well as depression right? I actually sometimes find stimulants, such as caffeine soothing. Maybe EMSAM in conjuction with a.
Emsam transdermal : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with selegiline include: antidepressants (including bupropion, maprotiline, mirtazapine), other MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, tranylcypromine), appetite suppressants (such as diethylpropion), drugs for attention deficit disorder (such as atomoxetine, methylphenidate), apraclonidine, buspirone, carbamazepine/oxcarbazepine, cyclobenzaprine, certain herbal products (such as ephedra/ma huang), cold medications/nasal decongestants (such as phenylephrine, phenylpropanolamine, pseudoephedrine), fentanyl, street drugs (such as LSD, mescaline), stimulants (such as amphetamines, ephedrine), supplements (such as tryptophan, tyramine), tetrabenazine, certain . Examples include street drugs such as MDMA/.
John's wort, dextromethorphan, certain antidepressants (including SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine, TCAs such as amitriptyline/doxepin), certain narcotic medications (such as meperidine, methadone, pentazocine, propoxyphene, tramadol, tapentadol), among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs. Tell your doctor or pharmacist if you are using any of these medications before, during, or within 2 weeks after treatment with selegiline. Tell your doctor or pharmacist if you have taken fluoxetine during at least 5 weeks before starting selegiline. Discuss with your doctor how much time to wait between starting or stopping any of these drugs and taking selegiline. Check the labels on all your medicines (such as allergy, cough- and- cold products, diet pills) because they may contain dextromethorphan, decongestants, or stimulants.
Ask your pharmacist about the safe use of those products. Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (such as diphenhydramine), anti- seizure drugs (such as phenytoin), medicine for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (such as codeine, fentanyl), psychiatric medicines (such as chlorpromazine, lithium, risperidone, trazodone).
It is very important that you follow special dietary restrictions in order to limit the amount of tyramine in your diet if you are using the higher strength patches (9 or 1. Avoid drinking large amounts of beverages containing caffeine (coffee, tea, colas) or eating large amounts of chocolate.
Caffeine can increase the side effects of this medication. Foods and beverages high in tyramine should be avoided while you are using this medication and for at least 2 weeks after you stop using this medication. Foods high in tyramine include: aged cheeses (cheddar, camembert, emmenthaler, brie, stilton blue, gruyere, gouda, brick, bleu, roquefort, boursault, parmesan, romano, provolone, liederdranz, colby, edam), aged/dried/fermented/salted/smoked/pickled/processed meats and fish (includes bacon, summer sausage, liverwurst, hot dogs, corned beef, pepperoni, salami, bologna, ham, mortadella, pickled or dried herring), banana peel, beef/chicken liver (stored, not fresh), bouillon cubes, commercial gravies, concentrated yeast extracts, fava beans, Italian green beans, broad beans, fermented bean curd, homemade yeast- leavened bread, kim chee (Korean fermented cabbage), orange pulp, overripe or spoiled fruits, packaged soups, red wine, sauerkraut, sherry, snow pea pods, sourdough bread, soy sauce, soybeans, soybean paste/miso, tofu, tap beer and ale, vermouth.
Moderate- to- low tyramine content foods include: alcohol- free beer, avocados, bananas, bottled beer and ale, chocolate and products made with chocolate, coffee, cola, cultured dairy products (e. Make sure laboratory personnel and all your doctors know you use this drug.